New-generation system redefines performance for GC-MS applications

ST. LOUIS--Laboratories performing food safety and authenticity, pharmaceutical, metabolomic, anti-doping and other analyses using gas chromatography-mass spectrometry (GC-MS) can now achieve new levels of performance using high-resolution accurate-mass (HRAM) Orbitrap mass spectrometry, bringing the highest level of detection and identification capabilities to GC-MS studies.

The new Thermo Scientific Q Exactive GC hybrid quadrupole-Orbitrap GC-MS/MS instrument represents the first-ever commercial system offering a combination of gas chromatography and HRAM Orbitrap mass spectrometry. This system is designed to provide the comprehensive characterization of samples in a single analysis for increased performance in compound discovery, identification and quantitation.

"Scientists all over the world have made tremendous scientific progress over the past decade using Orbitrap-based mass spectrometry with liquid chromatography,” said Sergio Guazzotti, director of marketing, GC-MS, Thermo Fisher Scientific. “Now, we are unlocking the power of Orbitrap technology for gas chromatography, providing GC-MS users with high resolving power and mass accuracy to deliver a deeper understanding of their samples than ever before.”

The Q Exactive GC system will be exhibited for the first time at the 63rdAnnual American Society for Mass Spectrometry Conference, Booth 140, and at the Landmark Suite at the Renaissance Hotel in St. Louis.

Early field collaborations with scientific leaders explored the application of this technology for both research and applied laboratories. Professor Joshua Coon, PhD, University of Wisconsin, Madison, applies GC-MS to metabolomic studies to understand complex biological systems. "While the LC-MS field has advanced rapidly over the past several years, largely driven by the impact of the Orbitrap mass analyzer, GC-MS could not offer comparable mass resolution and accuracy,” said Dr. Coon. “The introduction of the Q Exactive GC system is a game changer in this space. The combination of fast, predictable GC separations with accurate mass capabilities will translate to an increased ability to profile entire metabolomes."

Professor Jana Hajslova of the University of Chemical Technology, Prague, Czech Republic, is interested in food authenticity and origin as well as contaminant screening. "Our experience has shown us that the Q Exactive GC definitely brings a new level of performance into GC high-resolution mass spectrometry,” said Hajslova.

The Q Exactive GC system brings together qualitative and quantitative analyses by combining the high-precision, full scan HRAM capability of Orbitrap technology with the quantitative power of GC triple quadrupole technology. The system builds upon the flexible modularity of the Thermo Scientific TRACE 1300 Series GC, including user-exchangeable injectors and detectors. In laboratory tests, the Q Exactive GC system has shown quantitative capability equivalent to high-performing GC-MS triple quadrupole systems, especially when comparing analytical parameters such as sensitivity, precision and linearity.

This technology is designed to advance chemical analyses within laboratories limited by currently available full scan GC-MS technologies, such as time-of-flight (TOF) and quadrupole-time-of-flight (Q-TOF) mass spectrometry, or comparable technologies. Thermo Fisher Scientific expects the Q Exactive GC system will be useful for untargeted profiling experiments because it can add new capabilities to screening in food safety, forensic toxicology and anti-doping.

For more information on the Q Exactive GC system visit www.thermoscientific.com/QExactiveGC.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $17 billion and approximately 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support.
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IC-MS support to gold-standard Chromatography Data System

CHICAGO – Pittcon 2014 – Laboratory managers, scientists and technicians can now operate all their instruments using the same familiar software package with a new release of Thermo Scientific Dionex Chromeleon 7.2 Chromatography Data System (CDS) Service Release 1. 

The software now supports liquid and ion chromatography as well as gas chromatography coupled to mass spectrometry. Thermo Fisher Scientific will showcase the Chromeleon CDS at booth #2441 during Pittcon 2014, being held at McCormick Place in Chicago from March 2 - 6.

“Last year at Pittcon, we bridged the chromatography-mass spectrometry gap with the Chromeleon 7.2 CDS for GC-MS,” said Christoph Nickel, global software marketing director, chromatography, for Thermo Fisher. “Customer interest has been overwhelming, and this year we’re taking it to the next level by adding control of Thermo Scientific LC-MS instrumentation. With this new release, we’re responding to growing customer demand to apply high-sensitivity, information-rich MS techniques for quantitative applied analyses. Chromeleon CDS’s ease-of-use makes mass spec technology more accessible for routine operation.”

The latest version of the software adds full control for the Thermo Scientific MSQ single quadrupole system, TSQ Quantiva and Endura triple quadrupole instruments as well as the company’s benchtop Orbitrap-based high-resolution accurate mass instruments. This release enables CDS users to realize the benefits of Thermo Fisher Scientific’s LC-MS instrumentation in a familiar software environment with full scalability, remote access to instruments and data, and compliance with GLP, GMP, and 21 CFR Part 11 regulations.

Because lab personnel need to learn only one software package for a variety of chromatography and mass spectrometry instruments, laboratories can greatly reduce training requirements while improving productivity and the quality of results. The software also features one-click eWorkflows, designed to help users dramatically reduce method development time and quickly run and analyze samples, and built-in spreadsheet-type reporting to eliminate the need to export data.

Chromeleon 7.2 is designed around the concept of operational simplicity, to make it easy to move from samples to results. Microsoft®’s .NET architecture makes this latest generation CDS able to accommodate future needs.

For a closer look at the Chromeleon 7.2, visit Thermo Fisher at Pittcon booth #2441, or for more information, please visit www.thermoscientific.com/chromeleon. Follow Charlie Chromeleon at facebook.com/CharlieLovesChromatography.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Our four premier brands – Thermo Scientific, Life Technologies, Fisher Scientific and Unity Lab Services – offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support.
- See more at: http://www.thermoscientific.com/en/about-us/news/cds-supports-gc-ic-lc-enterprise-environments.html#sthash.mS9X4HlL.dpuf